Mounjaro vs Wegovy: Which is Better?
In the pursuit of effective weight management solutions, one may encounter a wide array of treatment options, such as weight loss injections. In those, Mounjaro delivers faster, greater weight loss, while Wegovy offers well-established safety and heart benefits.
To assist you in fine-tuning the process, we have drawn up a detailed comparison between Mounjaro and Wegovy, the two most widely discussed options in these injections, to help you identify what treatment suits your journey the best. Discover how they differ in terms of cost, effectiveness and suitability to help you make an informed decision about your weight loss plan.
What Are Wegovy and Mounjaro?
Wegovy and Mounjaro are medications for diabetes and weight loss that work by imitating certain hormones in your body, which are in charge of appetite regulation and blood sugar levels. They were originally developed solely to treat Type 2 diabetes but have since shown a dual purpose and are now also used for weight management.
How They Work in the Body
Wegovy (semaglutide) mimics the hormone GLP-1, stimulating the receptor which increases the feeling of fullness after a meal (satiety) and reduces appetite. It’s also in charge of delaying gastric emptying, a process which slows down how fast food leaves the stomach, which again boosts satiety. The overall impact helps you reduce your food intake and also have better blood sugar control.
Mounjaro (tirzepatide) mimics two hormones: GLP-1 and GIP. While GLP-1 performs the same functions as Wegovy, GIP helps the body use insulin more effectively and enhances fat metabolism. This means that blood sugar control is improved and there is less fat storage. It enhances utilisation of stored fat for energy, supporting metabolic efficiency and also plays a role in increasing satiety. It amplifies the physiological effects of GLP-1, making it more effective and giving Mounjaro an edge.
Wegovy vs Mounjaro: Effectiveness & Weight Loss Results
Mounjaro:
The SURMOUNT-1 clinical trial assessed weight loss in overweight individuals whilst taking Mounjaro compared to placebo. The trial included people who were overweight without diabetes. The results demonstrated over a period of 72 weeks, the average weight loss range by dose was:
- 5 mg: about 15.0%
- 10 mg: about 19.5–21.4%
- 15 mg: about 20.9–22.5%
At the highest dose (15mg), the average weight loss was up to 22.5% after 72 weeks.
Wegovy:
The STEP trials were a series of clinical studies looking at weight loss outcomes in overweight patients taking Wegovy, some who had diabetes. The results demonstrated that over a period of 68 weeks:
- Patients taking 2.4mg lost on average 14.9% of their body weight (obesity without diabetes)
- Patients taking 2.4 mg dose lost on average 9.6% of their body weight (obesity with type 2 diabetes)
More recently, the STEP-UP trial introduced a 7.2 mg dose of Wegovy, which showed a significant improvement in outcomes. Participants on this higher dose achieved an average weight loss of approximately 20.7%, bringing Wegovy’s performance closer to Mounjaro’s highest dose. This newer data positions Wegovy as a more competitive option for those seeking substantial weight loss.
So, both of these trials demonstrated that Mounjaro and Wegovy average at similar percentage weight loss at their maximum doses. However, the Surmount-1 trial demonstrated faster weight loss with Mounjaro. Patients saw significant results after 24-36 weeks, compared with the slower, steadier weight loss with Wegovy over 68 weeks.
Cost Comparison: Mounjaro vs Wegovy
For both medications, higher doses are more costly.
Mounjaro:
Our Mounjaro pricing ranges from £215 to £260 per month, depending on dosage: £215 (2.5 mg and 5 mg), £240 (7.5 mg), £250 (10 mg), and £260 (12.5 mg and 15 mg).
Wegovy:
At Weightless, Wegovy is priced as follows: £150 for 0.25 mg, £170 for 0.5–1 mg, £220 for 1.7 mg, and £270 for 2.4 mg.
Mounjaro and Wegovy are available on the NHS in the UK with strict restrictions. The user’s BMI must be greater than 35, or greater than 30 if the patient has an additional weight-related condition. ,
NHS access is low-cost but slow and highly restricted, while private clinics offer convenience and faster access at a higher cost. Patients should check with their local NHS provider for the most up-to-date access information.
Side effects: How Do They Compare?
Both medicines function in similar ways by mimicking GLP-1. They also have similar side effects, such as:
- Nausea,
- Vomiting,
- Diarrhoea
- Constipation
Mounjaro is known for stronger side effects as it works on two hormone pathways instead of one, and also results in weight loss more rapidly than Wegovy.
The rare risks and side effects of these drugs can include:
- Gallbladder issues
- Pancreatitis
- Kidney problems
Most users do not face these issues under proper medical supervision, however, it is important to inform a health care professional immediately under these circumstances.
Users have noted that side effects may increase as dosage increases, but are still manageable. Tolerability also improves as your body gets used to the medication, and the results are considered a worthwhile tradeoff.
Suitability: Who Should Consider Which?
While both injections offer effective weight loss results, it’s important to know they both suit different needs. Wegovy is recommended for those who are looking for a gradual start in weight loss, with milder side effects.
On the other hand, Mounjaro works faster and is recommended to those looking for faster results. It is typically better suited for people looking for more rapid weight loss as well as intense food cravings. Both medications require long-term commitment and careful supervision. Regular follow-ups with your healthcare provider are essential to ensure the treatment remains safe and effective, especially since these drugs impact appetite, digestion, and metabolic functions. Additionally, lifestyle changes such as healthy eating and physical activity play a crucial role alongside medication to achieve and maintain lasting weight loss results.
If you want faster, greater weight loss and can tolerate stronger effects, Mounjaro may suit you. If heart-health evidence and gradual weight loss matter more, Wegovy is a compelling choice. Either way, please consult your clinician to choose the safest option for your goals.
Summary Table: Wegovy vs Mounjaro at a Glance
Feature | Wegovy (Semaglutide) | Mounjaro (Tirzepatide) |
Purpose | Weight loss; originally for diabetes | Weight loss & diabetes (dual action) |
How it works | GLP-1 receptor agonist | Dual: GLP-1 + GIP receptor agonist |
Weight loss (avg) | ~15% over 68 weeks (STEP trials) | ~20%+ over 72 weeks (SURMOUNT-1) |
Speed of results | Gradual (several months) | Often faster weight loss (more noticeable in the first few months) |
Side effects | Nausea, constipation, fatigue | Nausea, constipation, fatigue |
Tolerance | Generally well-tolerated | May cause more intense side effects |
Dosing | Weekly injection (up to 2.4 mg) However 7.2mg expected soon. | Weekly injection (up to 15 mg) |
Expert Insights & User Tips
Without a doubt, Wegovy and Mounjaro dramatically reduce appetite. The constant cravings for sugary and junk foods typically diminish within the first few weeks, making this a clinically validated intervention that significantly improves quality of life and supports adherence to a healthy routine. Seeing early weight loss results, sometimes within weeks, can give a major mental boost, reinforcing motivation to eat better, move more, and stay on track.
It is recommended to start slowly and gradually with the help of medical professionals to help reduce side effects. Staying hydrated and exercising are also two major factors to keep in check. It is also very important to consult a doctor and keep them updated on all side effects to ensure the medication is safe for your health history. Experts suggest rotating between injection sites to avoid any skin irritation. Picking consistent days for medication and staying on schedule by setting reminders ensures a smooth treatment. Instead of self-diagnosing or worrying about severe side effects, it is recommended to contact a health care professional immediately.
If the dose is too high, appetite can be over-suppressed, resulting in a patient eating one small meal per day. In the long term, this will lead to protein (muscle) loss and malnutrition. It is important to keep up an exercise regime and a healthy diet to maintain overall health.
FAQs
Is Mounjaro better than Wegovy for weight loss?
Mounjaro targets 2 hormones, increasing the results of weight loss compared to Wegovy, which only targets one hormone. The weight loss tends to be more rapid in the short term. However, effectiveness may vary from individual to individual.
Some patients tolerate Wegovy much better, resulting in better success in the long term. Others are not looking for rapid weight loss that can be seen with Mounjaro.
Which is safer: Wegovy or Mounjaro?
Clinical trials suggest both medications are of equal safety with similar side effects.
Is Mounjaro stronger than Wegovy?
Yes, Mounjaro is considered stronger with greater appetite suppression due to its action on both GLP-1 and GIP receptors.
Which is more effective, Wegovy or Mounjaro?
Based on clinical evidence, Mounjaro works quicker and is more effective over time.
Can I go straight from Wegovy to Mounjaro?
Yes. It is possible to switch medications as long as it is done with the help of a medical professional. It is important to ensure there are no overlapping doses.
Is either covered by the NHS?
Wegovy is covered by the NHS, only provided to those in England who meet a certain criteria. Mounjaro is not covered by nhs as of now, and is only approved for type 2 diabetes.
Key takeaways:
- Both are injections for diabetes and weight loss. In the future, they may be prescribed for cardiac benefits too.
- Mounjaro targets two hormones (GLP-1 + GIP) while Wegovy targets GLP-1 only.
- Mounjaro shows faster, greater weight loss (22.5% over 72 weeks) vs Wegovy (15% but with the new higher dose, can go up to 20%)
- Wegovy is generally better tolerated.
- Side effects improve once the body gets used to a specific dose but can increase with increased doses.
- Private UK costs: Mounjaro (£215–£260/month), Wegovy (£150–£270/month).
- NHS access is limited and strictly regulated for both.
- Both require medical supervision, nutritional guidance and lifestyle changes for the maximum benefit.
- Switching between drugs is possible, but must be doctor-supervised.
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Disclaimer
At Weightless, we strive to provide accurate, up-to-date health information that is carefully reviewed by medical professionals. However, the content on this blog is intended for general knowledge only and should not be considered a substitute for medical advice, diagnosis, or treatment. Always speak with a qualified healthcare professional about any questions or concerns you may have regarding your health. Information here should not be used to make decisions about your personal care without professional guidance.
